Apr 18, 2011· Irbesartan (Aprovel ®, Avapro ®, Irbetan ®, Karvea ®) is a well established angiotensin receptor blocker, approved worldwide for the treatment of hypertension.In essential hypertension, irbesartan lowers blood pressure over 24 hours. The usual starting dosage is 150 mg once daily, but the dose can be uptitrated to 300 mg once daily if necessary.6 In many countries (US, Canada, Europe ...