Oct 02, 2019· Fluconazole side effects. Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).. Call your doctor at once if you have: fast or pounding heartbeats, fluttering in your chest, shortness of breath ...